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KMID : 1094020080250020073
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Journal of Veterinary Clinics
2008 Volume.25 No. 2 p.73 ~ p.78
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Ketamine Decreases Phagocytic Capacity of Canine Peripheral Blood Phagocytes In Vitro
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Kang Ji-Houn
Kim Min-Jun
Yang Mhan-Pyo
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Abstract
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Ketamine is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist and a short-acting general anaesthetic agent for human and veterinary use. We previously reported that treatment with ketamine impairs oxidative burst activity of canine peripheral blood leukocytes. In this study, the effect of ketamine on phagocytic capacity of canine peripheral blood leukocytes was examined in vitro. Phagocytic capacity was analyzed by using a flow cytometry. Ketamine directly decreased the phagocytic capacity of peripheral blood polymorphonuclear cells (PMN) and monocytes but not total peripheral blood mononuclear cells (PBMC). In addition, the phagocytic capacity of PMN and monocytes was inhibited by the ketamine-treated PBMC but not PMN culture supernatant. These results suggest that ketamine has a direct inhibitory effect on the phagocytic capacity of canine peripheral blood phagocytes and involves the production of soluble factor(s) from canine PBMC, which may suppress the phagocytic capacity.
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KEYWORD
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canine, ketamine, peripheral blood phagocytes, phagocytic capacity
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